Cysteine Proteinase Inhibitors

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro

Parasitology / Scanning Electron Microscopy / Humans / Mice / Female / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors

Download

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro

Parasitology / Scanning Electron Microscopy / Humans / Mice / Female / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors

Download

Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

Organic Chemistry / Humans / Molecular docking / Chagas disease / Enzyme / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors

Download

C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis

Fluorescence Resonance Energy Transfer / Peptides / Biochemical / Affinity chromatography / Fungal Pathogens / Pyridines / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors / Pyridines / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors

Download

Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells

Complementary and Alternative Medicine / Chromatography / Plant Biology / Mass Spectrometry / Breast Cancer / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay

Download

Survivin expression in human osteosarcoma is a marker for survival

Survival Analysis / Immunohistochemistry / Adolescent / Stratification / Fetal development / Humans / Child / Female / Osteosarcoma / Male / Cell Death / European / Aged / Middle Aged / Adult / Molecular Marker / Prognosis / Neoadjuvant Chemotherapy / Gene Family / Predictive value of tests / Nuclear Localization / Cysteine Proteinase Inhibitors / Humans / Child / Female / Osteosarcoma / Male / Cell Death / European / Aged / Middle Aged / Adult / Molecular Marker / Prognosis / Neoadjuvant Chemotherapy / Gene Family / Predictive value of tests / Nuclear Localization / Cysteine Proteinase Inhibitors

Download

A Cysteine Protease Inhibitor of Plasmodium berghei Is Essential for Exo-erythrocytic Development

Microbiology / Immunology / Medical Microbiology / Malaria / Humans / Mice / Animals / Fluorescent Antibody Technique / Hepatocytes / Transfection / Protozoan Proteins / Erythrocytes / Plasmodium berghei / Cysteine Proteinase Inhibitors / Mice / Animals / Fluorescent Antibody Technique / Hepatocytes / Transfection / Protozoan Proteins / Erythrocytes / Plasmodium berghei / Cysteine Proteinase Inhibitors

Download

Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy

Organic Chemistry / Mice / Muscular Dystrophy / Animals / Animal Model / Duchenne Muscular Dystrophy / Calpain / Amides / Molecular Structure / Cysteine Proteinase Inhibitors / Duchenne Muscular Dystrophy / Calpain / Amides / Molecular Structure / Cysteine Proteinase Inhibitors

Download

C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis

Fluorescence Resonance Energy Transfer / Peptides / Biochemical / Affinity chromatography / Fungal Pathogens / Pyridines / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors / Pyridines / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors

Download

Crystal Structure of Glycyl Endopeptidase from Carica papaya: A Cysteine Endopeptidase of Unusual Substrate Specificity

Biochemistry / Macromolecular X-Ray Crystallography / Crystal structure / Sequence alignment / Plants / Carica papaya / Substrate Specificity / Cysteine endopeptidases / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology / cystatin B / Cysteine Proteinase Inhibitors / Carica papaya / Substrate Specificity / Cysteine endopeptidases / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology / cystatin B / Cysteine Proteinase Inhibitors

Download

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro

Parasitology / Scanning Electron Microscopy / Humans / Mice / Female / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors

Download

Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells

Complementary and Alternative Medicine / Chromatography / Plant Biology / Mass Spectrometry / Breast Cancer / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay / Neutral Red / Ethnopharmacology / Medicinal Plants / Magnetic Resonance Spectroscopy / Apoptosis / Western blotting / Caspases / Humans / Lancet / Caco-2 cells / Neoplasms / Asclepiadaceae / Acylation / Cell Proliferation / Structure activity Relationship / Structural Similarity Index / Cell Survival / Glycosides / Molecular Structure / Cysteine Proteinase Inhibitors / MTT assay / Neutral Red

Download

Sindbis virus induces apoptosis through a caspase-dependent, CrmA-sensitive pathway

Virology / DNA damage / Apoptosis / Biological Sciences / Cell line / Brain / Mice / Animals / Spinal Cord / Cell Death / Programmed cell death / Tumor necrosis factor-alpha / Sindbis virus / Cysteine endopeptidases / Cowpox virus / Cysteine Proteinase Inhibitors / Brain / Mice / Animals / Spinal Cord / Cell Death / Programmed cell death / Tumor necrosis factor-alpha / Sindbis virus / Cysteine endopeptidases / Cowpox virus / Cysteine Proteinase Inhibitors

Download

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

Multidisciplinary / Humans / Animals / Plasmodium falciparum / Gene Targeting / Cysteine endopeptidases / Base Sequence / Erythrocytes / Cysteine Proteinase Inhibitors / Cysteine endopeptidases / Base Sequence / Erythrocytes / Cysteine Proteinase Inhibitors

Download

C-Npys (S-3-nitro-2-pyridinesulfenyl) and peptide derivatives can inhibit a serine-thiol proteinase activity from Paracoccidioides brasiliensis

Fluorescence Resonance Energy Transfer / FRET / Peptides / Biochemical / Affinity chromatography / Fungal Pathogens / Pyridines / PCM / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors / Fungal Pathogens / Pyridines / PCM / Cysteine endopeptidases / Serine Protease / Therapeutic Use / Paracoccidioides / Biochemistry and cell biology / Molecular Structure / Cysteine Proteinase Inhibitors

Download